Research Topics

  • Elucidating the role of cortactin in endothelial and epithelial barrier function and leukocyte transmigration
  • Characterizing the role of actin and actin-binding molecules for the stabilization of endothelial and epithelial junctions during inflammation

  • Investigating the role of the cortactin homologue HS1 in integrin activation and leukocyte transmigration during inflammation

  • Characterizing the role of actin filament dynamics during leukocyte-endothelial interactions in cortactin- and HS1-deficient mice

  • Examining the role of cortactin and HS1 in intestinal permeability
  • Investigating the role of cortactin and HS1 in cerebral cavernous malformations, development of sepsis and the severity of leukemia
  • Investigating the role of cortactin in murine infection models